Chronic Thromboembolic Pulmonary Hypertension  

Oleh:

Piazza, Gregory ; Goldhaber, Samuel Z.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 364 no. 04 (Jan. 2011), page 351-360.
Topik: HYPERTENSION; Pulmonary Embolism; Pathophysiology

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Chronic thromboembolic pulmonary hypertension is defined as mean pulmonary-artery pressure greater than 25 mm Hg that persists 6 months after pulmonary embolism is diagnosed. The 2008 World Symposium on Pulmonary Hypertension emphasized the importance of chronic thromboembolic pulmonary hypertension, which occurs in 2 to 4% of patients after acute pulmonary embolism. The frequency of this condition among patients with pulmonary hypertension is unknown. Patients with chronic thromboembolic pulmonary hypertension generally present in their 40s, although this condition has been reported in patients in other age groups.2 The diagnosis is often overlooked because many patients do not have a history of clinically overt pulmonary embolism. The natural history of chronic thromboembolic pulmonary hypertension has been difficult to determine because a subgroup of patients have had occult pulmonary embolism, with subtle clues to the diagnosis that became apparent only in retrospect. Patients with chronic thromboembolic pulmonary hypertension typically have a honeymoon period after acute pulmonary embolism, during which symptoms are absent despite the onset of pulmonary hypertension. Long-term follow-up of patients with chronic thromboembolic pulmonary hypertension, including those with mild symptoms and those who are asymptomatic, is needed to elucidate the natural history of this disease.

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