Necrotizing Enterocolitis  

Oleh:

Neu, Josef ; Walker, W. Allan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 364 no. 03 (Jan. 2011), page 255-264.
Topik: Neonates; Necrotizing Enterocolitis

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Necrotizing enterocolitis is among the most common and devastating diseases in neonates. It has also been one of the most difficult to eradicate1 and thus has become a priority for research.2 Conditions closely resembling necrotizing enterocolitis were described before the 1960s, but the entity was not widely recognized until after the advent of modern neonatal intensive care.1 Since that time, the incidence of necrotizing enterocolitis and the associated morbidity and mortality have remained unchanged because of ever-improving survival of the smallest infants; in some instances, these rates have actually increased. On the basis of large, multicenter, neonatal network databases from the United States and Canada, the mean prevalence of the disorder is about 7% among infants with a birth weight between 500 and 1500 g.3-6 The estimated rate of death associated with necrotizing enterocolitis ranges between 20 and 30%, with the highest rate among infants requiring surgery.7 The excessive inflammatory process initiated in the highly immunoreactive intestine in necrotizing enterocolitis extends the effects of the disease systemically, affecting distant organs such as the brain and placing affected infants at substantially increased risk for neurodevelopmental delays.8,9 Indeed, an infant recovering from necrotizing enterocolitis may have nearly a 25% chance of microcephaly and serious neurodevelopmental delays that will transcend concerns that pertain to the gastrointestinal tract.10 In many centers, concern that enteral feeding is associated with the development of necrotizing enterocolitis has resulted in an increased duration of intravenous nutrition in infants, potentially increasing the risk of infectious complications and the length of hospitalization.11

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