Dietary cysteine is used more efficiently by children with severe acute malnutrition with edema compared with those without edema  

Oleh:

Badaloo, Asha ; Hsu, Jean W. ; Taylor-Bryan, Carolyn ; Green, Curtis

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 95 no. 01 (Jan. 2012), page 84-90 .
Topik: Energy and Protein Metabolism; Edematous Severe Acute Malnutrition; SAM
Fulltext: A07 v95 n1 p84 kelik2022.pdf (197.44KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Children with edematous severe acute malnutrition (SAM) produce less cysteine than do their nonedematous counterparts. They also have marked glutathione (GSH) depletion, hair loss, skin erosion, gut mucosal atrophy, and depletion of mucins. Because GSH, skin, hair, mucosal, and mucin proteins are rich in cysteine, we hypothesized that splanchnic extraction and the efficiency of cysteine utilization would be greater in edematous than in nonedematous SAM. Objective: We aimed to measure cysteine kinetics in childhood edematous and nonedematous SAM. Design: Cysteine flux, oxidation, balance, and splanchnic uptake (SPU) were measured in 2 groups of children with edematous (n = 9) and nonedematous (n = 10) SAM at 4.4 ± 1.1 d after admission (stage 1) and at 20.5 ± 1.6 d after admission (stage 2) when they had replenished 50% of their weight deficit. Results: In comparison with the nonedematous group, the edematous group had slower cysteine flux at stage 1 but not at stage 2; furthermore, they oxidized less cysteine at both stages, resulting in better cysteine balance and therefore better efficiency of utilization of dietary cysteine. Cysteine SPU was not different between groups but was ~45% in both groups at the 2 stages. Conclusion: These findings suggest that children with edematous SAM may have a greater requirement for cysteine during early and mid–nutritional rehabilitation because they used dietary cysteine more efficiently than did their nonedematous counterparts and because the splanchnic tissues of all children with SAM have a relatively high requirement for cysteine.

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