Detail Peripheral Brain-Derived Neurotrophic Factor Levels in Alzheimer's Disease and Mild Cognitive Impairment: a Comprehensive Systematic Review and Meta-analysis (article of Molecular Neurobiology, Vol 54 Iss 9 November 2017, pp 7297–7311) Bibliografi Author: Bo Yi Kim ; Seon Heui Lee ; Graham, Petra L ; Angelucci, Francesco ; Lucia, Alejandro ; Pareja-Galeano, Helios ; Leyhe, Thomas ; Turana, Yuda ; I Re Lee ; Ji Hye Yoon ; Jae Il Shin Topik: Alzheimer'sdisease; Mild cognitive impairment; BDNF; Biomarkers; JABFUNG-FKIK-YDT-2021-02 Bahasa: (EN )     Penerbit: Springer Science and Business Media New York     Tahun Terbit: 2016     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: BA2.11 Peripheral Brain-Derived Neurotrophic Factor Levels.pdf (615.0KB; 3 download) B2 Jurnal Internasional Bereputasi dan Berfaktor dampak.pdf (564.01KB; 2 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract Alzheimer’s disease (AD) is becoming a growing global problem, and there is an urgent need to identify reliable blood biomarkers of the risk and progression of this condition. A potential candidate is the brain-derived neurotrophic factor (BDNF), which modulates major trophic effects in the brain. However, findings are apparently inconsistent regarding peripheral blood BDNF levels in AD patients vs. healthy people. We thus performed a systematic review and meta-analysis of the studies that have examined peripheral BDNF levels in patients with AD or mild cognitive impairment (MCI) and healthy controls. We searched articles through PubMed, EMBASE, and hand searching. Over a total pool of 2061 potential articles, 26 met all inclusion criteria (including a total of 1584 AD patients, 556 MCI patients, and 1294 controls). A meta-analysis of BDNF levels between early AD and controls showed statistically significantly higher levels (SMD [95 % CI]: 0.72 [0.31, 1.13]) with no heterogeneity. AD patients with a low (<20) mini-mental state examination (MMSE) score had lower peripheral BDNF levels compared with controls (SMD [95 % CI]: -0.33 [-0.60, -0.05]). However, we found no statistically significant difference in blood (serum/plasma) BDNF levels between all AD patients and controls (standard mean difference, SMD [95 % CI]: -0.16 [-0.4, 0.07]), and there was heterogeneity among studies (P < 0.0001, I 2 = 85.8 %). There were no differences in blood BDNF levels among AD or MCI patients vs. controls by subgroup analyses according to age, sex, and drug use. In conclusion, this meta-analysis shows that peripheral blood BDNF levels seem to be increased in early AD and decreased in AD patients with low MMSE scores respectively compared with their age- and sex-matched healthy referents. At present, however, this could not be concluded from individual studies. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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