Sperm caspase-9 in oligoasthenoteratozoospermic men with and without varicocele  

Oleh:

Zalata, Adel ; Abdel-Khabir, Ahmed ; El-Bayoumy, Youssef ; El-Mogy, Mohamed

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 05 (Nov. 2011), page 1097-1099.
Topik: Male infertility; semen; sperm; apoptosis; caspase-9; varicocele

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To assess sperm caspase-9 activity in infertile oligoasthenoteratozoospermic (OAT) men with and without varicocele. Design Prospective. Setting Academic setting. Patient(s) Eighty men: healthy fertile control subjects (n = 20), OAT (n = 25), and OAT associated with left-side varicocele (n = 35). Intervention(s) History taking, clinical examination, semen analysis,assessment of seminal caspase-9. Main Outcome Measure(s) Semen analysis, sperm caspase-9. Result(s) Sperm caspase-9 was significantly increased in infertile OAT men associated with varicocele compared with OAT men without varicocele and healthy fertile control subjects. Sperm casapse-9 activity demonstrated significant negative correlation with sperm count, sperm motility, sperm velocity, sperm linear velocity, sperm linearity index, and sperm normal morphology. Conclusion(s) Sperm caspase-9 is exaggerated in infertile OAT cases with varicocele compared with infertile OAT cases without varicocele or healthy fertile men. Sperm caspase-9 demonstrated significant negative correlation with semen variables.

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