Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome  

Oleh:

Wallace, Kedra L. ; Johnson, Venessia ; Sopelak, Victoria ; Hines, Randall S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 04 (Oct. 2011), page 1051-1056.
Topik: Polycystic ovary syndrome; clomiphene citrate; letrozole; leukemia inhibitory factor; angiogenesis

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To compare the effect of clomiphene citrate (CC) and letrozole on endometrial receptivity in women with polycystic ovary syndrome (PCOS). Design A randomized controlled trial. Setting University teaching hospital. Patient(s) Ten anovulatory women with PCOS and 5 fertile ovulatory women. Intervention(s) Patients received 2.5 mg of letrozole on cycle days 3–7 (5 patients, 1 cycle) or 50 mg of CC on cycle days 5–9 (5 patients, 1 cycle). Main Outcome Measure(s) Serum estrogen (E) and progesterone (P) endometrial protein and messenger RNA (mRNA) expression of leukemia inhibitory factor (LIF), dickkhopf homolog 1 (DKK-1), fibroblast growth factor 22 (FGF-22), and endometrial mRNA expression of LIF/GP130 receptor (LIFR). Result(s) No statistically significant differences were observed between groups compared with fertile ovulatory women when serum E and P were examined, or between body mass index (BMI), and cycle day at time of biopsy. Letrozole increased mRNA expression of LIF, DKK1, LIFR, and FGF-22, whereas CC only increased endometrial mRNA expression of LIF. Letrozole mRNA expression directly translated into increased protein expression of like genes in the endometrium. The CC protein expression of DKK-1 was significantly decreased compared with controls. Conclusion(s) Letrozole positively influences a number of markers of endometrial receptivity compared with CC.

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