Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization  

Oleh:

Bloom, Michael S. ; Kim, Dongsul ; Saal, Frederick S. vom ; Taylor, Julia A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 03 (Sep. 2011), page 672-677.
Topik: Bisphenol A (BPA); estradiol (E2); follicle; in vitro fertilization (IVF); ovary

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate associations between serum bisphenol A (BPA) concentrations and follicular response to exogenous ovary stimulation. Design Fasting serum was prospectively collected on the day of oocyte retrieval and assessed for unconjugated BPA using high-performance liquid chromatography with Coularray detection. Multivariable linear regression and negative binomial regression were used to assess associations between concentrations of BPA and outcome measures. Models were adjusted for race/ethnicity, antral follicle count at baseline, and cigarette smoking. Setting A reproductive health center. Patient(s) Forty-four women undergoing IVF. Intervention(s) None. Main Outcome Measure(s) Peak E2 level and the number of oocytes retrieved during IVF. Result(s) The median unconjugated serum BPA concentration is 2.53 ng/mL (range = 0.3–67.36 ng/mL). Bisphenol A is inversely associated with E2 (ß = -0.16; 95% confidence interval = -0.32, 0.01), as well as with E2 normalized to the number of mature-sized follicles at the hCG trigger (ß = -0.14; 95% confidence interval = -0.24, -0.03). No association is observed for BPA and the number of oocytes retrieved (adjusted risk ratio = 0.95; 95% confidence interval = 0.82, 1.10). Conclusion(s) Bisphenol A is associated with a reduced E2 response during IVF. Although limited by the preliminary nature of this study, these results merit confirmation in a future comprehensive investigation.

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