Cycle scheduling with oral contraceptive pills in the GnRH antagonist protocol vs the long protocol: a randomized, controlled trial  

Oleh:

Garcia-Velasco, Juan A. ; Bermejo, Alfonso ; Ruiz, Francisco ; Martinez-Salazar, Javier

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 03 (Sep. 2011), page 590-593.
Topik: Oral contraceptive pills; GnRH antagonist; long protocol; cycle scheduling; IVF

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To compare cycle outcomes after scheduling with the standard long protocol versus the use of oral contraceptive pills (OCPs) in patients undergoing GnRH antagonist cycles. Design Prospective, randomized, controlled trial. Setting University-affiliated private assisted reproduction center. Patient(s) Regularly cycling women aged =38 years with fewer than three previous IVF attempts were enrolled. Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were exclusion criteria. Intervention(s) One hundred fifteen patients received OCP (0.030 ethinyl E2/0.15 desogestrel) for 12–16 days, and controlled ovarian hyperstimulation was started on day 5 after OCP treatment; similarly, 113 patients received the long protocol from day 20–22 of the previous cycle. Main Outcome Measure(s) The primary outcome was ongoing pregnancy rate; secondary outcome variables were clinical pregnancy rate, live birth rate, implantation rate, and miscarriage rate. Result(s) Patients receiving the GnRH antagonist treatment showed a lower peak serum E2 (1,334 vs. 1,823 pg/mL) but similar peak serum PE (0.58 vs. 0.65 ng/mL), lower duration of the stimulation (10.3 vs. 11.4 days) with similar FSH consumption (1,613 vs. 1,807 IU), and ovarian response (10.2 vs. 11.7 oocytes). No differences were observed in the fertilization rates (68.1% vs. 64.8%), total number of embryos obtained (5.9 vs. 6.2), mean number of embryos transferred (1.8 vs. 1.8), implantation rate (36% vs. 39%), miscarriage rate (8.9% vs. 17%), ongoing pregnancy rate (47.8% vs. 53.9%), or live birth rate (44.3% vs. 47%). Conclusion(s) Comparable outcomes can be obtained using OCP containing 0.030 ethinyl E2/0.15 desogestrel to schedule patients undergoing the antagonist protocol.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali