Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5a-reductase genes (SRD5A1 and SRD5A2)  

Oleh:

Caglayan, A. Okay ; Dundar, Munis ; Tanriverdi, Fatih ; Baysal, Nuran A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 02 (Aug. 2011), page 479-482.
Topik: 5a-reductase; aromatase; expression; idiopathic hirsutism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To evaluate idiopathic hirsutism etiology via molecular studies testing peripheral and local aromatase and 5a-reductase expression. Design Assessment of the expression of messenger RNA (mRNA) for type 1 and 2,5a-reductase isoenzyme gene (SDR5A1, SDR5A2) and aromatase (CYP19A) in dermal papillae cells and peripheral blood mononuclear cells. Setting University hospital. Patient(s) 28 untreated idiopathic hirsute patients and 20 healthy women (controls). Intervention(s) Human skin biopsies and peripheral venous blood. Main Outcome Measure(s) SDR5A1, SDR5A2, CYP19A gene expression in skin biopsies and peripheral blood. Result(s) A statistically significant reduction of SRD5A1, SRD5A2, and CYP19A gene expression was found in the dermal papillae cells and peripheral blood mononuclear cell between the study and control group. Conclusion(s) Further study, including protein expression and enzyme activity assays, are warranted to characterize the paradoxically low gene expression levels of local 5a-reductase and aromatase in women with idiopathic hirsutism.

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