The reproductive and metabolic effect of rosiglitazone on Chinese women with polycystic ovarian syndrome—a double-blind randomized placebo-controlled study  

Oleh:

Lam, Po Mui ; Tam, Wing Hung ; Ching, Wan Ma Ronald ; Cheung, Lai Ping

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 02 (Aug. 2011), page 445-451.
Topik: Polycystic ovary syndrome; rosiglitazone; insulin resistance; hyperandrogenism; Chinese

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate whether an insulin sensitizer has any effect on amenorrhea and clinical and biochemical hyperandrogenism in Chinese women with polycystic ovarian syndrome (PCOS). Design Randomized controlled double-blind trial. Setting A tertiary referral center, Hong Kong. Patient(s) Chinese women who fulfilled the Rotterdam criteria of PCOS (n = 70). Intervention(s) Rosiglitazone 4 mg daily for the first month followed by 4 mg twice daily for 11 months. Main Outcome Measure(s) Menstrual status as well as clinical and biochemical hyperandrogenism. Result(s) There is a significantly higher rate of regular menses among the treatment arm (16 [50.0%] of 32 vs 4 [11.8%] of 34) at 6 months and the improvement appeared to be sustained (10 [41.7%] of 24 vs 6 [20.0%] of 30) at 12 months. There was no change in the acne and hirsutism scores as well as serum T levels in both arms. Conclusion(s) We found a possible benefit in menstrual cyclicity but a lack of improvement in hyperandrogenism in our Chinese population.

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