Outcome of cycles of oocyte in vitro maturation requiring testicular sperm extraction for nonobstructive azoospermia  

Oleh:

Fadini, Rubens ; Colpi, Elisabetta ; Renzini, Mario Mignini ; Coticchio, Giovanni

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 02 (Aug. 2011), page 321-323.
Topik: Oocytes; in vitro maturation; nonobstructive azoospermia; fertilization; pregnancy rate

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To assess the applicability of oocyte IVM in case of nonobstructive azoospermia (NOA). Design Case series. Setting Private IVF unit. Patient(s) All male partners were affected by NOA. Twenty-one women (20 normo-ovulatory and 1 with polycystic ovary) underwent 27 IVM treatments. The outcome of controlled ovarian stimulation (COS) cycles in normo-ovulatory women whose partners were affected by NOA was assessed for comparison. Intervention(s) Spermatozoa from testicular sperm extraction (TESE) samples were retrieved and cryopreserved before treatment. Main Outcome Measure(s) Rates of fertilization, pregnancy per cycle and transfer, and implantation. Result(s) Twenty-seven IVM-TESE cycles were carried out in 21 women. Fertilization rate was 64.4%. In compliance with national legislation, no more than three oocytes were inseminated in each cycle and all developing embryos were transferred. Six single clinical pregnancies were ascertained (22.2% and 27.3% pregnancy rates per cycle and per transfer, respectively). One pregnancy ended in abortion. The others developed to term and gave rise to five healthy babies. Sixty couples underwent standard COS-TESE treatment. Rates of fertilization, clinical pregnancy per cycle, implantation, and abortion were 64.6%, 20.0%, 11.3%, and 16.7%, respectively. Eleven babies were born from ten pregnancies. Conclusion(s) Oocyte IVM may represent an option in NOA cases.

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