woman with premature ovarian failure induced by Tripterygium wilfordii Hook.f. gives birth to a healthy child  

Oleh:

Chen, Xin ; Chen, Shi-ling

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 01 (Jul. 2011), page e19-e21.
Topik: premature ovarian failure; Tripterygium wilfordii Hook.f.; elevated FSH; birth

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To inform clinicians about the reproductive damage of Tripterygium wilfordii Hook.f. (TW) associated with subsequent premature ovarian failure. Design Case report. Setting Reproductive medicine center in a university-affiliated hospital. Patient(s) A 36-year-old infertile woman presenting amenorrhea and elevated FSH levels (65.56 mIU/mL) after using TW. Intervention(s) Estradiol valerate, two month course of oral contraceptives, GnRH agonist, stimulation cycle with urine FSH, triggered ovulation using 5000 IU of hCG and IVF-ET. Main Outcome Measure(s) Serum hormone levels, antral follicle count (AFC), oocyte retrieval number, embryo quality and birth. Result(s) Serum hormone levels and AFC of the POF woman were restored, and she gave birth to a healthy child after IVF-ET. Through IVF-ET she was found to have had oocyte and granulosa cell damage because of TW. Conclusion(s) This is a real-life manifestation of reproductive damage of TW. The medicamentous amenorrhea, hormone levels and AFC decline induced by TW are reversible, but oocyte and granulosa cell damage may be irreversible. This will help clinicians to avoid using TW for nulligravida.

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