Bisphenol-A exposure alters endometrial progesterone receptor expression in the nonhuman primate  

Oleh:

Aldad, Tamir S. ; Rahmani, Nora ; Leranth, Csaba ; Taylor, Hugh S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 01 (Jul. 2011), page 175-179.
Topik: Bisphenol-A (BPA); estrogen; progesterone receptor (PR); endocrine disruptor; xenoestrogen; endometriosis; endometrial hyperplasia

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate the effect of bisphenol-A (BPA), a xenoestrogen endocrine disruptor, on endometrial P receptor (PR) expression in nonhuman primates and human cells. Design Controlled trial in primates. Setting University. Animal(s) African green monkeys. Intervention(s) After oophorectomy, BPA (50 µg/kg/d), E2, both, or vehicle control were administered. Estradiol and BPA were used in Ishikawa cells. Main Outcome Measure(s) Progesterone receptor expression using immunohistochemistry and quantitative polymerase chain reaction. Result(s) Progesterone receptor expression was increased in E2-treated primates compared with controls. Exposure to the combination of E2 and BPA resulted in decreased PR expression compared with E2 exposure alone. In Ishikawa cells treated with E2, PR expression increased 5.1-fold; however, when Ishikawa cells were simultaneously treated with E2 and BPA, PR expression was decreased to 0.6-fold that of cells treated with E2 alone. Conclusion(s) Bisphenol-A alone functions as a weak estrogen. However, when administered with E2, BPA diminishes E2-induced PR expression. The estrogen-like effect of BPA reported in exposed humans may be mediated by PR blockade and a resultant decrease in the estrogen inhibition normally imparted by P. Diminished PR expression may underlie previous reports linking BPA exposure to endometrial dysfunction in humans.

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