Involvement of estrogen receptor-related receptors in human ovarian endometriosis  

Oleh:

Cavallini, Aldo ; Resta, Leonardo ; Caringella, Anna Maria ; Dinaro, Edoardo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 01 (Jul. 2011), page 102-106.
Topik: Ovarian endometriosis; estrogen receptor; estrogen receptor-related receptor

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To determine whether decreased estrogen receptor alpha (ER-a) expression in endometriotic lesions could be balanced by an increased expression of estrogen receptor-related receptors (ERRs). To evaluate whether ERR-a expression is influenced by hormonal change in fertile and menopausal women. Design Prospective controlled study. Setting University Hospital, Department of Gynecology. Patient(s) Twenty-five women: 20 women of reproductive age with (n = 10) and without (control; n = 10) endometriosis and 5 menopausal women. Intervention(s) Real-time polymerase chain reaction (qPCR). Immunohistochemistry. Main Outcome Measure(s) The ER and ERR expression levels were studied by reverse transcriptase–qPCR, ELISA, and immunohistochemistry using endometriotic and normal endometrial tissues. The ERR-a protein distribution was performed by immunohistochemistry in fertile and menopausal women. Result(s) Increased levels of ER-ß were associated with ER-a, ERR-a, and ERR-? reductions in ectopic tissue but not in eutopic and normal endometria. Similar levels of ERR-ß were found in women with and without endometriosis. The ERR-a expression was similar in proliferative and secretory endometrial samples, whereas a down-regulation of this receptor was found in atrophic tissue. Conclusion(s) Our data confirm the up-regulation of ER-ß as the principal receptor involved in the progression of human endometriosis. In addition, we found that ERR-a seems to be unresponsive to hormonal changes during the menstrual cycle.

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