Cigarette smoke condensate exposure delays follicular development and function in a stage-dependent manner  

Oleh:

Sadeu, Jean Clair ; Foster, Warren G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 07 (Jun. 2011), page 2410-2417.
Topik: Cigarette smoke condensate; smoking; follicle culture; folliculogenesis; oocyte maturation; estradiol; progesterone

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To determine the effects of cigarette smoke condensate (CSC) on follicular development and function from the early preantral stage through ovulation. Design Prospective laboratory study. Setting Academic research environment. Animal(s) Female F1 hybrid (C57BL/6j×CBA/Ca) mice. Intervention(s) Mouse early preantral follicles (100–130 µm) were exposed to increasing concentrations of CSC (0 µg/mL [control] to 130 µg/mL) during in vitro growth and ovulation. Main Outcome Measure(s) Follicular development, follicle survival, gonadal steroid output, expansion of the cumulus–oocyte complex, oocyte growth, and maturation. Result(s) Cigarette smoke condensate exposure significantly inhibited follicular development in the preantral and antral stage and decreased follicle survival at 90 µg CSC/mL and higher. Estradiol output was significantly lower in CSC-exposed (90 and 130 µg/mL) follicles. Before ovulation, CSC significantly increased P output, which decreased thereafter. Cigarette smoke condensate exposure reduced cumulus–oocyte complex expansion and subsequently reduced the number of polar body oocytes. Conclusion(s) Cigarette smoke condensate exposure inhibits follicle development and leads to premature luteinization of the preovulatory follicle, with decreased oocyte maturation in a mouse isolated follicle culture system that mimics murine folliculogenesis in vivo.

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