Successful treatment of unresponsive thin endometrium  

Oleh:

Gleicher, Norbert ; Vidali, Andrea ; Barad, David H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 06 (May 2011), page 2123.e13-.
Topik: Granulocyte colony-stimulating factor; in vitro fertilization (IVF); endometrial thickness; inadequate endometrium; implantation; pregnancy chance

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To assess whether inadequate, thin endometrium (<7 mm), after failure to expand with standard treatment options, will be responsive to cytokine treatment. Design Prospective cohort study of four patients. Setting Two independent IVF centers in New York City. Patient(s) Four consecutive women undergoing IVF who, after standard endometrial preparation, still demonstrated highly inadequate endometrium. Intervention(s) Transvaginal endometrial perfusion with granulocyte colony-stimulating factor (G-CSF). Main Outcome Measure(s) Endometrial thickness on day of ET, with pregnancy as secondary endpoint. Result(s) We report successful endometrial expansion to at least minimal thickness of 7 mm after uterine perfusion with G-CSF in four patients previously resistant to treatment with estrogen and vasodilators. All four patients therefore reached ET, and all four also conceived, although one pregnancy required termination because of intramural, corneal ectopic location. Endometrial expansion to minimal thickness occurred within approximately 48 hours from infusion. Conclusion(s) Uterine perfusion with G-CSF represents a promising new tool for the currently mostly intractable problem of inadequate, thin endometrium. This treatment also deserves further investigation for its potential to improve implantation chances in association with IVF and, therefore, pregnancy rates.

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