The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994–2010)  

Oleh:

Kleiman, Sandra E. ; Yogev, Leah ; Lehavi, Ofer ; Hauser, Ron

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 06 (May 2011), page 2005-2012.
Topik: Y-chromosome microdeletion; AZF microdeletion; male infertility; sperm cells; spermatogenesis

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To reassess the predictive value of detecting sperm cells in men with AZFb or AZFb-c deletions. Design Retrospective analysis of previously reported men with AZFb or AZFb-c deletions and the addition of six new cases. Setting Fertility institution. Patient(s) Men with both sequence tagged site marker identification and testicular cytology/histology findings. Intervention(s) Systematic review of reported men with microdeletions that included eligibility, data extraction and analysis. Main Outcome Measure(s) Availability of sperm cells for intracytoplasmic sperm injection (ICSI) in men with AZFb/AZFb-c microdeletions. Result(s) The average prevalences reported for AZFb, AZFb-c, partial AZFb, and partial AZFb-c in azoospermic men were 0.9% ± 0.07%, 2.7% ± 0.93%, 1.23% ± 0.9%, and 1% ± 0.6%, respectively. Sperm cells were identified in 7% and 3% of the 28 and 71 men with complete AZFb and AZFb-c and in 57% and 43% of the 14 and 7 men with partial AZFb and AZFb-c deletions, respectively. The likelihood of finding sperm cells in men with complete versus partial AZFb and AZFb-c deletions was significantly lower. As yet, no clinical or chemical pregnancy after ICSI in cases with complete AZFb/b-c microdeletions has been reported. Conclusion(s) Determining the extent of AZFb or AZFb-c deletions is critical considering the frequency and the reasonable prospect of finding sperm cells in partial AZFb/AZFb-c deletions. Referring men with complete AZFb/b-c microdeletions to testicular sperm extraction/ICSI programs should be revaluated.

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