Decreased fertility among female childhood cancer survivors who received 22–27 Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study  

Oleh:

Green, Daniel M. ; Nolan, Vikki G. ; Kawashima, Toana ; Stovall, Marilyn

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 06 (May 2011), page 1922-1927.
Topik: CANCER; CHILDHOOD DISEASES; Childhood cancer survivor; hypothalamic irradiation; pituitary irradiation; alkylating agent; pregnancy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To evaluate the effect of hypothalamic/pituitary radiation (HPT RT) dose on the occurrence of first pregnancy. Design Retrospective cohort study of childhood cancer 5-year survivors (CCS) diagnosed between 1970 and 1986 before 21 years of age at one of 26 North American pediatric cancer treatment centers. Setting Self-administered questionnaire. Patient(s) A total of 3,619 female CCS who participated in the Childhood Cancer Survivor Study and received no or scatter (=0.1 Gy) radiation to the ovaries and 2,081 female siblings (Sibs) of the participants. Intervention(s) None. Main Outcome Measure(s) Self-reported pregnancy events. Result(s) As a group, CCS were as likely to report being pregnant as Sibs (hazard ratio 1.07, 95% confidence interval 0.97–1.19). Multivariable models showed a significant decrease in the risk of pregnancy with HPT RT doses =22 Gy compared with those CCS receiving no HPT RT. Conclusion(s) These results support the hypothesis that exposures of 22–27 Gy HPT RT may be a contributing factor to infertility among female CCS.

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