Expression of Glucose Transporter-1, Hypoxia-inducible Factor-1a, Phosphatidylinositol 3-kinase and Protein Kinase B (Akt) in Relation to [18F]Fluorodeoxyglucose Uptake in Nasopharyngeal Diffuse Large B-cell Lymphoma: a Case Report and Literature Review  

Oleh:

Fang, J. ; Luo, X-M. ; Yao, H-T. ; Zhou, S-H. ; Ruan, L-X. ; Yan, S-X.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 06 (Nov. 2010), page 2160-2168.
Topik: Diffuse Large B-Cell Lymphoma; Nasopharynx; Glucose Transporter-1; Glut-1; Protein Kinase B; Akt; Positron Emission Tomography/Computed Tomography
Fulltext: s32.pdf (325.3KB)

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Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This report presents a case of nasopharyngeal diffuse large B-cell lymphoma and a literature review concerning the use of [18F]fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). A 37-year old man was admitted to hospital complaining of nasal secretions with minor epistaxis and a 20-year history of snoring. Nasal endoscopy found diffuse swelling in the nasopharynx and a biopsy was performed. Prior to chemotherapy, FDG-PET/CT showed softtissue diffuse thickening and FDG accumulation in the nasopharynx and bilateral cervical lymph nodes; FDG did not accumulate elsewhere. After four cycles of chemotherapy (rituximab, cyclo phosphamide, doxorubicin, vincristine) and prednisone treatment, FDG-PET/CT showed that FDG still accumulated in the nasopharynx and bilateral cervical lymph nodes, therefore radiotherapy was initiated. At 1 year, FDG-PET/CT showed no FDG accumulation. Immunohistochemical analysis revealed that the tumour was positive for phosphorylated protein kinase B (Akt), suggesting that FDG uptake may be associated with factors activated by the phosphatidylinositol 3-kinase/Akt signalling pathway.

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