Immunological Effects of Laparoscopic and Open Cholecystectomy  

Oleh:

Wu, H.Y. ; Li, F. ; Tang, Q.F.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 06 (Nov. 2010), page 2077-2083.
Topik: Laparoscopic Cholecystectomy; Open Cholecystectomy; Chemokine; Immunomodulator; Interleukin-18; Monocyte Chemotactic Protein-1
Fulltext: s23.pdf (115.16KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This prospective, randomized, controlled study evaluated plasma levels of interleukin-18 (IL-18) and monocyte chemotactic protein-1 (MCP-l) in patients undergoing cholecystectomy. Forty patients were randomized to undergo laparoscopic cholecystectomy (LC) or open cholecystectomy (OC). Plasma concentrations of IL-18 and MCP-1 were measured before anaesthesia (T0), before operation (T1), 30 min after the start of the operation (T2) and at the end of the operation (T3). Compared with T0, the IL-18 concentration was significantly increased at T2 and T3 in both groups. In addition, the MCP-1 concentration was significantly increased at T3 compared with T0 in the LC group. Both the IL-18 and MCP-1 concentrations were significantly lower in the OC group than in the LC group at T3. It is suggested that carbon dioxide pneumoperitoneum may cause immunodepression, that epidural anaesthesia can attenuate the stress response, and that IL-18 and MCP-1 are sensitive markers for evaluating the patient's immune function.

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