Expression of Hypoxia Inducible Factor-1a and Its Significance in Laryngeal Carcinoma  

Oleh:

Wu, X-H. ; Lu, Y-F. ; Hu, X-D. ; Mao, J-Y. ; Ji, X-X. ; Yao, H-T ; Zhou, S-H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 06 (Nov. 2010), page 2040-2046.
Topik: Laryngeal Carcinoma; Hypoxia Inducible Factor-1 Alpha; Tnm Stage; Immunohistochemistry
Fulltext: s18.pdf (185.74KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This study examined levels of hypoxia inducible factor-1a (HIF-1a) protein in 40 laryngeal squamous cell carcinoma specimens using immunohistochemistry. Correlations between HIF-1a immunoreactivity and patient age, tumour lymph node metastasis stage, histological grade (extent of differentiation), and alcohol and smoking history were evaluated. Of the tumour tissues obtained, 35 (87.5%) were located in the glottic area and five (12.5%) in the supraglottic area. All patients were male and aged between 35and 71 years; 12 (30.0%) presented with lymph node metastases, 24 (60.0%) had cancer classified as T1 or T2, and 16 (40.0%) as high clinical stage (T3 or T4). The pattern of HIF-1a protein localization in tumour tissues, when present, was mixed nuclear/cytoplasmic, with positive HIF-1a expression in 27 patients (67.5%). Differences in HIF-1a levels in samples from different tumour stages and in those with lymph node-positive versus lymph node-negative cancers were statistically significant.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali