Evaluation of Iloprost to Prevent Vasospasm in Coronary Artery Bypass Grafts  

Oleh:

Ege, T. ; Gur, O. ; Karadag, C.H. ; Duran, E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 05 (Sep. 2010), page 1759-1763.
Topik: Iloprost; Coronary Artery Bypass; Arterial Graft; Vein Graft
Fulltext: s21.pdf (94.03KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study assessed the efficacy of iloprost in relieving vasospasm in coronary artery bypass grafts. Radial artery (RA), left internal thoracic artery (LITA) and saphenous vein (SV) grafts were taken from 20 patients (13 men and seven women, mean age 63.8 years [range 48 - 74 years]) scheduled to undergo coronary artery bypass grafting. Ten 3 mm vascular rings were cut from each graft and kept under tension for at least 60 min. They were kept alive with 37 °C oxygenated Krebs solution. Smooth muscle contraction was achieved with phenylephrine before iloprost was administered every 2 min, starting at a concentration of 10-9 mol/l and increasing in logarithmic increments to a concentration of 10-5 mol/l. The vasodilation response to iloprost started in all samples at a concentration of 10-9 mol/l and increased with each incremental increase in iloprost concentration up to 10-5 mol/l. These data suggest that local administration of iloprost has a role in relieving graft vasospasm during harvesting and preparation for coronary artery bypass grafting.

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