Plasticity for Affective Neurocircuitry : How the Environment Affects Gene Expression  

Oleh:

Fox, Nathan A. ; Hane, Amie A. ; Pine, Daniel S.

Jenis: Article from Journal - e-Journal
Dalam koleksi: Current Directions in Psychological Science vol. 16 no. 01 (Feb. 2007), page 1-5.
Topik: Temperament; Gene × Environment Interaction; Attention Bias To Threat; Parenting
Fulltext: 01. Plasticity for Affective Neurocircuitry - How the Environment Affects Gene Expression.pdf (108.38KB)

Isi artikel

We (Fox et al., 2005) recently described a gene by- environment interaction involving child temperament and maternal social support, finding heightened behavioral inhibition in children homozygous or heterozygous for the serotonin transporter (5HTTLPR) gene short allele whose mothers reported low social support. Here, we propose a model, Plasticity for Affective Neurocircuitry, that describes the manner in which genetic disposition and environmental circumstances may interact. Children with a persistently fearful temperament (and the 5HTTLPR short allele) are more likely to experience care-giving environments in which threat is highlighted. This in turn will exacerbate an attention bias that alters critical affective neurocircuitry to threat and enhances and maintains anxious behavior in the child.

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