French adults’ cognitive performance after daily supplementation with antioxidant vitamins and minerals at nutritional doses: a post hoc analysis of the Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) trial  

Oleh:

Kesse-Guyot, Emmanuelle ; Fezeu, Leopold ; Jeandel, Claude

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 94 no. 03 (Sep. 2011), page 892-899 .
Topik: Mineral Antioxidants; Nutritional Epidemiology; Public Health
Fulltext: Am J Clin Nutr-2011-Kesse-Guyot-892-9.pdf (390.15KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Antioxidant properties of some vitamins and trace elements may help to prevent cognitive decline. Objective: The aim of the current study was to estimate the long-term effects of antioxidant nutrient supplementation on the cognitive performance of participants in the Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) study 6 y after the end of the trial. Design: This study included 4447 French participants aged 45–60 y who were enrolled in the SU.VI.MAX study (1994–2002), which was a double-blind, placebo-controlled, randomized trial. From 1994 to 2002, participants received daily vitamin C (120 mg), ß-carotene (6 mg), vitamin E (30 mg), selenium (100 µg), and zinc (20 mg) in combination or as a placebo. In 2007–2009, the cognitive performance of participants was assessed with 4 neuropsychological tests (6 tasks). Principal components analysis (PCA) was performed to identify cognitive-function summary scores. Associations between antioxidant supplementation and cognitive functions, in the full sample and by subgroups, were estimated through ANOVA and expressed as mean differences and 95% CIs. Subgroup analyses were performed according to baseline characteristics. Results: Subjects receiving active antioxidant supplementation had better episodic memory scores (mean difference: 0.61; 95% CI: 0.02, 1.20). PCA indicated 2 factors that were interpreted as showing verbal memory and executive functioning. Verbal memory was improved by antioxidant supplementation only in subjects who were nonsmokers or who had low serum vitamin C concentrations at baseline. Conclusion: This study supports the role of an adequate antioxidant nutrient status in the preservation of verbal memory under certain conditions.

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