Disrupted fat distribution and composition due to medium-chain triglycerides in mice with a ß-oxidation defect  

Oleh:

Tucci, Sara ; Flogel, Ulrich ; Sturm, Marga ; Borsch, Elena ; Spiekerkoetter, Ute

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 94 no. 02 (Aug. 2011), page 439-449 .
Topik: Fatty Acid; Nutritional Status; Dietary Intake; Body Composition
Fulltext: Am J Clin Nutr-2011-Tucci-439-49.pdf (1.18MB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Because of the enhanced recognition of inherited long-chain fatty acid oxidation disorders by worldwide newborn screening programs, an increasing number of asymptomatic patients receive medium-chain triglyceride (MCT) supplements to prevent the development of cardiomyopathy and myopathy. Objective: MCT supplementation has been recognized as a safe dietary intervention, but long-term observations into later adulthood are still not available. We investigated the consequences of a prolonged MCT diet on abdominal fat distribution and composition and on liver fat. Design: Mice with very-long-chain acyl-coenzyme A dehydrogenase deficiency (VLCAD-/-) were supplemented for 1 y with a diet in which MCTs replaced long-chain triglycerides without increasing the total fat content. The dietary effects on abdominal fat accumulation and composition were analyzed by in vivo 1H- and 13C-magnetic resonance spectroscopy (9.4 Tesla). Results: After 1 y of MCT supplementation, VLCAD-/- mice accumulated massive visceral fat and had a dramatic increase in the concentration of serum free fatty acids. Furthermore, we observed a profound shift in body triglyceride composition, ie, concentrations of physiologically important polyunsaturated fatty acids dramatically decreased. 1H-Magnetic resonance spectroscopy analysis and histologic evaluation of the liver also showed pronounced fat accumulation and marked oxidative stress. Conclusion: Although the MCT-supplemented diet has been reported to prevent the development of cardiomyopathy and skeletal myopathy in fatty acid oxidation disorders, our data show that long-term MCT supplementation results in a severe clinical phenotype similar to that of nonalcoholic steatohepatitis and the metabolic syndrome.

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