Dietary macronutrient composition affects ß cell responsiveness but not insulin sensitivity  

Oleh:

Goree, Laura Lee T ; Chandler-Laney, Paula ; Ellis, Amy C

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 94 no. 01 (Jul. 2011), page 120-127 .
Topik: Carbohydrate Metabolism; Diabetes
Fulltext: Am J Clin Nutr-2011-Goree-120-7.pdf (128.91KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Altering dietary carbohydrate or fat content may have chronic effects on insulin secretion and sensitivity, which may vary with individual metabolic phenotype. Objective: The objective was to evaluate the contribution of tightly controlled diets differing in carbohydrate and fat content for 8 wk to insulin sensitivity and ß cell responsiveness and whether effects of diet would vary with race, free-living diet, or insulin response. Design: Healthy overweight men and women (36 European Americans, 33 African Americans) were provided with food for 8 wk and received either a eucaloric standard diet (55% carbohydrate, 27% fat) or a eucaloric reduced-carbohydrate (RedCHO)/higher-fat diet (43% carbohydrate, 39% fat). Insulin sensitivity and ß cell responsiveness were assessed at baseline and 8 wk by using a liquid meal tolerance test. Results: Insulin sensitivity did not change with diet (P = 0.1601). Static ß cell response to glucose (?S) was 28.5% lower after the RedCHO/higher-fat diet. Subgroup analyses indicated that lower ?S with the RedCHO/higher-fat diet occurred primarily among African Americans. A significant inverse association was observed for change in glucose area under the curve compared with change in ?S. Conclusions: Consumption of a eucaloric 43% carbohydrate/39% fat diet for 8 wk resulted in down-regulation of ß cell responsiveness, which was influenced by baseline phenotypic characteristics. Further study is needed to probe the potential cause-and-effect relation between change in ?S and change in glucose tolerance.

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