Increased vitamin E intake is associated with higher a-tocopherol concentration in the maternal circulation but higher a-carboxyethyl hydroxychroman concentration in the fetal circulation  

Oleh:

Didenco, Svetlana ; Gillingham, Melanie B ; Go, Mitzi D. ; Leonard, Scott W ; Traber, Maret G. ; McEvoy, Cindy T

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 93 no. 02 (Feb. 2011), page 368-373 .
Topik: vitamin E; Metabolites Carboxyethyl Hydroxychromans; Pregnant Women; a-carboxyethyl hydroxychroman
Fulltext: Am J Clin Nutr-2011-Didenco-368-73.pdf (82.32KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: The transfer of vitamin E across the placenta is limited, but no data exist on the concentrations of vitamin E metabolites carboxyethyl hydroxychromans (a- and ?-CEHCs) in the fetal circulation. Objective: We measured a- and ?-CEHC concentrations in maternal and umbilical cord blood pairs and examined their relations to circulating vitamin E (a- and ?-tocopherol) and maternal dietary vitamin E intake. Design: Healthy, pregnant women were enrolled from Oregon Health and Science University's obstetric clinic (<22 wk gestation), and at least one fasting blood sample and a previous day's 24-h diet recall were collected during their pregnancy (n = 19). Umbilical cord blood samples were obtained at the time of delivery and were analyzed for a- and ?-tocopherol, a- and ?-CEHC, and total lipid concentrations. Results: Mean (±SD) concentrations of umbilical cord blood a-CEHC (30.2 ± 28.9 nmol/L) and ?-CEHC (104.5 ± 61.3 nmol/L) were not significantly different from maternal concentrations (P = 0.07 and 0.08, respectively), but metabolite:tocopherol ratios were significantly higher in cord blood (P < 0.01 and 0.001, respectively). Maternal a-tocopherol:total lipids ratios were correlated with cord blood a-CEHCs (r = 0.67, P = 0.004), and higher vitamin E intakes were associated with higher cord blood a-CEHC concentrations (r = 0.75, P < 0.003). Conclusion: Higher maternal intake of vitamin E during pregnancy may result in increased metabolite concentrations in the fetal circulation, suggesting increased maternal or fetal liver metabolism of vitamin E.

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