The Evolutionary Persistence of Genes That Increase Mental Disorders Risk  

Oleh:

Keller, Matthew C

Jenis: Article from Journal - e-Journal
Dalam koleksi: Current Directions in Psychological Science vol. 17 no. 06 (Dec. 2008), page 395-399.
Topik: Mental Disorders; Genetics; Evolution; Mutation-Selection; Balancing Selection; Schizophrenia
Fulltext: 08. The Evolutionary Persistence of Genes That Increase Mental Disorders Risk.pdf (109.88KB)

Isi artikel

Natural selection constantly removes those genetic variants (alleles) that even slightly decrease average reproductive success. Yet, given the high heritabilities and prevalence rates of severe mental disorders, human populations seem to be awash in deleterious alleles. Evolutionary genetics offers an illuminating framework for understanding why mental disorder risk alleles have persisted despite natural selection, and this framework can help guide future research in behavioral and psychiatric genetics.

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