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ArtikelNo Hiding Place; AIDS  
Oleh: [s.n]
Jenis: Article from Bulletin/Magazine
Dalam koleksi: The Economist (http://search.proquest.com/) vol. 400 no. 8743 (Jul. 2011), page 67.
Topik: Acquired Immune Deficiency Syndrome-- AIDS; Human Immunodeficiency Virus--HIV; Medical Research; Antiretroviral Drugs
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  • Perpustakaan Pusat (Semanggi)
    • Nomor Panggil: EE29.67
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Isi artikelAIDS researchers are rightly pleased with the progress they have made. In particular, the use of antiretroviral drugs has not only revolutionised treatment of HIV infection, but also offers the prospect of stopping the spread of the virus. In a matter of weeks, these drugs reduce the number of viruses per millilitre of infected blood from millions to less than 50. But good as they are at keeping viral levels low, antiretrovirals never destroy the virus completely and thus cure the patient once and for all. There are two reasons. One is that, although HIV reproduces mainly in immune-system cells called T-cells, it also lives in certain cells of the brain, gut and lymph nodes. In these cells it is protected from the drugs by mechanisms that are, as yet, not fully understood. The other is that even in T-cells it sometimes stops replicating and becomes dormant. Since antiretrovirals work by interfering with the process of replication, dormant viruses are immune to their effects. Take the drugs away, and when a dormant virus wakes up again it will rapidly reinfect the body it is in. The search for a cure for AIDS, then, has led only to frustration.
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