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The Amount of Surface HLA-I on T Lymphocytes Decreases in Breast Infiltrating Ductal Carcinoma Patients
Oleh:
S, Zhao
;
X, Yang
;
N, Lu
;
Y, Zhang
;
X, Li
;
Y, Li
;
Y, Zhou
;
F, Wan
;
X, Zou
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
The Journal of International Medical Research vol. 39 no. 02 (Mar. 2011)
,
page 508-513.
Topik:
Breast Infiltrating Ductal Carcinoma
;
Human Leucocyte Antigen Class I
;
T Lymphocytes
;
Immune Escape
Fulltext:
1612.pdf
(94.98KB)
Ketersediaan
Perpustakaan FK
Nomor Panggil:
J11.K
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Human leucocyte antigen class I (HLA-I), which includes HLA-A, -B and -C, is an essential immune factor participating in the antitumour immune response. The changes in HLA-I expression in peripheral blood T lymphocytes in cancer patients have yet to be defined. This study examined the expression of HLA-I on CD4+ and CD8+ T lymphocytes in female patients with stage I – IV breast infiltrating ductal carcinoma, benign breast tumour diseases (mammary intraductal papilloma or breast fibroadenoma), and in healthy controls. HLA-I was down-regulated on CD4+ T lymphocytes from patients with stage III and IV cancer, and on CD8+ T lymphocytes in patients with stage I – IV cancer compared with healthy controls. HLA-I expression in T lymphocytes may contribute towards immune-balance disorders in tumour patients.
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