Pathological Features and Prognosis in Chronic Hepatitis B Virus Carriers  

Oleh:

Lu Z.H. ; Wei Chen ; Ju Z.C. ; Pei H. ; Yang X.J. ; Gu X.B. ; Huang L.H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 01 (Mar. 2011), page 71-77.
Topik: HEPATITIS B; Chronic Hepatitis B Virus Carrier; Hepatitis B Reactivation; Liver Biopsy; Liver Pathology
Fulltext: 1568.pdf (106.97KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This retrospective study examined 220 Chinese chronic hepatitis B virus carriers over 5 years. After initial liver biopsy, liver function tests and serological analysis, patients underwent further tests of liver function and hepatitis B seromarkers at 6-month intervals. Second and third liver biopsies were performed in 56 and 23 patients, respectively. Liver pathology was classified according to inflammatory activity (G0 - G4) and degree of fibrosis (S0 - S4). A significantly greater proportion of hepatitis B e antigen antibody-positive patients had a more severe level of inflammation and fibrosis than patients who were hepatitis B e antigen (HBeAg)-positive. Abnormal inflammation (= G2) occurred in 122 (55.5%) patients. Hepatitis B reactivation occurred in 35 (15.9%) patients: 33 had obvious liver inflammation at the initial biopsy (= G2) and only two had a low level of liver inflammation (G0 - G1). The hepatitis B reactivation rate was significantly related to age but not to gender. Hepatitis B surface antigen clearance was 1.55% per year and HBeAg seroconversion was 5.36% per year. In conclusion, hepatitis B reactivation was closely correlated with age and the level of liver inflammation.

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