Excisional cone as fertility-sparing treatment in early-stage cervical cancer  

Oleh:

Fagotti, Anna ; Gagliardi, Maria Lucia ; Moruzzi, Cristina ; Carone, Vito ; Scambia, Giovanni ; Fanfani, Francesco

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 03 (Mar. 2011), page 1109-1112.
Topik: CANCER; Cervical cancer; fertility-sparing; conization; pelvic lymphadenectomy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To describe a case series of early-stage cervical cancer patients treated with excisional cone instead of radical trachelectomy as fertility-sparing surgery. Design Prospective study. Setting University hospital. Patient(s) Early-stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA2–IB1), age =45 years, tumor =20 mm. Intervention(s) Cold-knife conization and laparoscopic pelvic lymphadenectomy. Main Outcome Measure(s) Recurrence and pregnancy rate. Result(s) There were 17 patients: 4 (23.5%) IA2, 13 (76.5%) IB1; 12 (70.5%) squamous cell carcinoma, 4 (23.5%) adenocarcinoma, and 1 (6%) glassy cell tumor. Four cases (23.5%) involved lymphovascular space invasion. The median number of lymph nodes removed was 18 (range 13–51). None of the patients received neoadjuvant chemotherapy, and two patients (12%) received three courses of adjuvant chemotherapy. No recurrences were observed after a median follow-up of 16 months (range 8–101 months). Two of five patients (40%) attempting to conceive had a spontaneous pregnancy and delivery. Conclusion(s) In selected and informed patients, conization and laparoscopic pelvic lymphadenectomy seems to be feasible as a fertility-sparing surgical approach.

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