Background. In the 21th century, we could get fastfood containing high sugar content, caramelized product, and aluminium foil packaged food easily. The sendentary habbit accompanied by consuming fast food made the body degenerate faster than usual. Medical research now focused on preventive approach such as exercise as a treatment to prevent degenerative disease.
Objectives. This research aims to know the hepatoprotective effect of aerobic exercise against D-galactose and AlCl3 induced in Mus musculus C57BL/6J.
Methods. This research used experimental method using two groups of Mus musculus C57BL/6J (3 mice in each group) which was injected D-galactose (90 mg/kg body weight) and AlCl3 (40 mg/kg body weight) intraperitoneal. The second group was given swimming exercise for 30 minutes each day (5 days in a week). We
used HE staining and scored the bile duct proliferation, fatty change, fibrosis, pseudoglandular architecture.
Results. The group which was given aerobic exercise has 3 bile duct proliferations per portal vein, and fatty change (second grade). The group which was not given has bile duct proliferations per portal vein, fatty change (first grade).
Conclusions. Aerobic exercise which was conducted 30 minutes for 5 days in a week showed more bile duct proliferations per portal vein and raised the fatty change
scoring. |