Background. Degenerative liver disease is one of the main health problem in the world. Liver cell degeneration can be caused by oxidative stress which is formed when the cell reoxigenate because of the increasing number of ROS (Reactive Oxygen Species) and nitrogen species. D-galactose and AlCl3 are substances that are usually found in the earth and can cause the formation of ROS. Antioxidants, like lycopene which can be found in tomato is expected to prevent liver disease, especially that is caused by liver degeneration.
Objectives. This research aims to know about the hepatoprotective effect of lycopene extract after the induction of d-galactose and AlCl3.
Methods. This research is an experimental research using two groups of Mus musculus C57BL/6J (3 mice in every group) that was induced by d-galactose and
AlCl3 and the second group was given lycopene extract after the induction. The data was analyzed by descriptive method.
Results. Group which was given lycopene extract after induction of d-galactose and AlCl3 had longer life span (67 days) compared to the group which was only induced by d-galactose and AlCl3. Histologically, steatosis wasn’t found in this group liver, average of 1 bile duct proliferation around every portal vein, fibrosis and pseudoglandular wasn’t found. Beside that, group that was only induced by dgalactose and AlCl3 had first grade of steatosis, average of 1 bile duct proliferation
around every portal vein, fibrosis and pseudoglandular also wasn’t found in this group.
Conclusions. In group that was only induced by d-galactose and AlCl3, steatosis was found in more severe degree compared to the group that was given lycopene extract after induction. There’s no other histological difference between this two groups. |