Background: D-galactose and aluminium are free radicals that can be found in daily life, such as from food, cosmetics, and drugs. Cocoa is rich of antioxidant and widely produced in Ineonesia. It is rich of flavanols, a group of antioxidant capable of attenuating the effects of free radicals.
Objectives. This study aims to analyse the hepatoprotective effect of on D-galactose and AlCl3 induced Mus musculus C5BL/6J liver.
Methods. This experimental study used two groups of Mus musculus C57BL/6J. Both groups of Mus musculus C57BL/6J were injected with D-galactose and AlCl3 peritoneally, while only the second group received cocoa. Liver tissue was taken and analyzed for bile duct proliferation, fibrosis, liver steatosis, pseudoglandular and other histopathological features.
Results. Bile duct proliferation was found more prominent in second group compared to first group. Liver steatosis was found in the first group and was not found in the second group while fibrotic tissue and pseudoglandular were absent in both groups.
Conclusions. Cocoa has hepatoprotective effect against liver degeneration, especially steatosis that was induced with D-galactose and AlCl3. |