Background. Diabetes mellitus is a pandemic disease that causes of death and disability worldwide. The prevalence of diabetes mellitus continues to increase
annually. Soursop leaves (Annona muricata) can be used as an alternative medicine to lower blood sugar levels in people with diabetes mellitus.
Methodology. The design of this study was experimental in vivo. The study used 30 Rattus norvegicus rats strain Sprague Dawley that induced with alloxan. Rats were
divided into 5 groups, each containing 6 rats; a group of normal mice, a group of diabetic rats, a group given Glibenclamide, a group given soursop leaf extract of
100 mg / kgBW, and a group given soursop leaf extract 200 mg / kgBW.
Interventions were performed for 21 days and blood sugar checks were performed on days 0, 3, 7, 14, and 21 using Glucose test strips and tools from Easy Touch GCU. Data analysis using Saphiro-Wilk test, Paired T test, One Way ANOVA test, and Post-Hoc Bonferroni test.
Results. The results showed that the data were normally distributed (Saphiro-Wilk test p> 0.05). Provision of soursop leaf extract at doses of 100 and 200 mg / kgBW
for 21 days showed a significant decrease in blood sugar levels (Paired T test p <0.05). There was a difference of decrease of blood glucose level between treatment group (One Way ANOVA test p <0,05) but statistically there was no significant difference of effectivity between treatment group (Post-Hoc Bonferroni p> 0,05).
Conclusion. Soursop leaf extract was proven to reduce blood sugar levels of alloxan-induced rats (p = 0.000). Soursop leaf extract dose 100 and 200 mg / kgBB
both can lower blood sugar levels. |