Short-term change in growth of uterine leiomyoma: tumor growth spurts  

Oleh:

Baird, Donna Day ; Garrett, Tiana A. ; Laughlin, Shannon K. ; Davis, Barbara ; Semelka, Richard C. ; Peddada, Shyamal D.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 01 (Jan. 2011), page 242-246 .
Topik: Uterine leiomyoma; tumor growth; fibroid size; ethnic disparity; magnetic resonance imaging; lon gitudinal study; short-term variability

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To describe the short-term changes in growth of uterine leiomyomas (fibroids). Design Prospective observational study. Setting University research center. Patient(s) Premenopausal women with fibroids (18 blacks and 18 whites) recruited through a physician network and community outreach. Intervention(s) Not applicable. Main Outcome Measure(s) The volumes of 101 fibroids were measured at enrollment, 3, 6, and 12 months with magnetic resonance imaging, resulting in three interval-specific growth rates. Growth spurts were defined by interval growth rates =30% per 3 months and substantially greater than during other intervals of observation. An overall measure of short-term change in fibroid growth was calculated as the variance of the three interval-specific growth rates. Result(s) Growth spurts were observed in 37 of the 101 fibroids, a prevalence nearly tenfold higher than that attributable to potential measurement error. Fibroids from the same woman did not have similar short-term growth, nor were woman-specific factors (age, race/ethnicity, parity, body mass) or the fibroid position in the uterus important. However, large fibroids (>5 cm diameter) had less short-term change than smaller fibroids. Conclusion(s) Short spurts of growth are common for fibroids, suggesting that tumor biology may change rapidly.

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