The impact of a gonadotropin-releasing hormone antagonist on gonadotropin ovulation induction cycles in women with polycystic ovary syndrome: a prospective randomized study  

Oleh:

Stadtmauer, Laurel A. ; Sarhan, Abbaa ; Duran, E. Hakan ; Beydoun, Hind ; Bocca, Silvina

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 01 (Jan. 2011), page 216-220.
Topik: Ovulation induction; IUI; GnRH antagonist; PCOS

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To evaluate the effect of the gonadotropin-releasing hormone antagonist Ganirelix on gonadotropin ovulation induction (OI) in patients with polycystic ovary syndrome (PCOS). Design Prospective, randomized, controlled study. Setting Academic infertility center. Patient(s) Ninety-eight anovulatory women with PCOS undergoing 154 gonadotropin OI cycles. Intervention(s) Patients were treated with recombinant FSH alone (group 1) or in conjunction with Ganirelix when the leading follicle was =13 mm (group 2) versus from the beginning of stimulation (group 3), followed by IUI. Main Outcome Measure(s) Per cycle clinical pregnancy rate (CPR), live-birth rate (LBR), total gonadotropin dose, days of stimulation, serum LH and peak E2, and premature luteinization rate. Result(s) Data are suggestive of improved CPR in group 2 versus group 1 (33% vs. 19%) and LBR (35% vs. 20%) but not significantly different. Premature luteinization was highest in group 1 (21% vs. 1.8% in group 2 and 2.1% in group 3). Group 3 had the highest cancellation rate and cost without improving CPR and LBR. No differences were noted in peak serum E2, total gonadotropin dose, or days of stimulation. Conclusion(s) Adding Ganirelix in a flexible protocol to gonadotropin OI cycles in women with PCOS may be beneficial by decreasing premature luteinization.

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