Ovulation rate in adolescents with type 1 diabetes mellitus  

Oleh:

Codner, Ethel ; Eyzaguirre, Francisca C. ; Iniguez, German ; Lopez, Patricia ; Perez-Bravo, Francisco

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 01 (Jan. 2011), page 197-202.
Topik: Adolescence; fertility; menarche; ovarian function; ovulation; pregnancy; puberty; type 1 diabetes mellitus

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To study ovulation in adolescents with type 1 diabetes (T1D) and the effect of hemoglobin A1c (HbA1c) levels on their ovulatory function. Design Prospective investigation. Setting Academic research institute. Patient(s) Adolescents with T1D (n = 31) and healthy girls (n = 52). Intervention(s) Ovulation assessed through the measurement of salivary progesterone (days 13, 18, 23, and 28 of each cycle). Main Outcome Measure(s) Proportion of ovulatory cycles. Result(s) A total of 168 and 281 menstrual cycles were studied in the T1D and control girls, respectively. Metabolic control was defined as optimal if HbA1c was <7.5%. The proportion of ovulatory cycles was similar in the TID and control groups (34.5% and 36.3%, respectively). Regression analyses showed that the presence of T1D did not have a statistically significant effect on the ovulatory rate. However, more ovulatory cycles were observed in girls with T1D who had optimal metabolic control compared with those who had insufficient control (51.3% vs. 29.4%). Conclusion(s) In adolescent girls, T1D did not affect the rate of ovulation. A higher ovulatory rate was observed in those with optimal control compared with those with insufficient metabolic control, but a substantial proportion of ovulatory cycles were still observed in patients with higher HbA1c levels.

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