Levels of follicular G-CSF and interleukin-15 appear as noninvasive biomarkers of subsequent successful birth in modified natural in vitro fertilization/intracytoplasmic sperm injection cycles  

Oleh:

Ledee, Nathalie ; Frydman, Rene ; Osipova, Agnessia ; Taieb, Joelle ; Gallot, Vanessa

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 01 (Jan. 2011), page 94-98.
Topik: G-CSF; interleukin-15; follicular fluid; oocyte; pregnancy; monitored natural cycle; IVF/ICSI; biomarker

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Design A retrospective blinded study. Setting European network of research, Embryo Implantation Control (EMBIC). Patient(s) Single FF from 83 women were analyzed during a modified natural IVF/ICSI cycle, and reproducibility of follicular composition was evaluated over two cycles for 15 patients. Intervention(s) Each FF sample was blindly tested to assess levels of 26 factors by bead-based immunoassays. Main Outcome Measure(s) Each mediator was evaluated as a potential biomarker of subsequent birth by multivariate regression analysis. Result(s) A combination of both FF G-CSF and IL-15 was the optimal model to predict birth (AUCROC, 0.85). Birth rates per cycle were 48.9% (16/33) if two good-prognosis criteria were present (FF G-CSF >12 pg/mL and IL-15 <7 pg/mL) and 8% (3/36) and 0% (0/14) if, respectively, one or none were present. FF G-CSF was significantly correlated over two cycles (r = .71), suggesting a possible prognostic value of its documentation. Conclusion(s) Combined follicular G-CSF and IL-15 quantification appears as an efficient and noninvasive method to define oocyte competence for subsequent successful conception in modified natural IVF/ICSI cycles.

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