Hippocampal Volume and Sensitivity to Maternal Aggressive Behavior: A Prospective Study of Adolescent Depressive Symptoms  

Oleh:

Whittle, Sarah ; Yap, Marie B.H. ; Sheeber, Lisa ; Dudgeon, Paul ; Yücel, Murat ; Pantelis, Christos ; Simmons, Julian G. ; Allen, Nicholas B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 23 no. 1 (Feb. 2011), page 115-129.
Topik: biological factors; depressive symptoms; depressive disorders; hippocampal volume

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.20 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset depressive disorders. Given the critical role of the hippocamus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volume more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali