Perbandingan Efek Antidislilpidemia Antara Minyak Zaitun (Olea europaea L.) Jenis Extra Virgin Olive Oil Dan Simvastatin Terhadap Profil Lipid Tikus Putih  

Oleh:

Dewanti, Gemma Ayu ; Silvyningrum, Thianti ; Pribadi, Fajar Wahyu

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Mandala of Health (A Scientific Journal) vol. 04 no. 03 (Sep. 2010), page 152-163.
Topik: olive oil; Simvastatin; Lipid profile

Ketersediaan

Perpustakaan FK Nomor Panggil: M50.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Dyslipidemia is the main factor in formating atherosclerosis, which bused in coroner heart disease. Besides consuming anti dislipidemia drugs, the alternative therapy of dislipidemia is consumption of olive oil. The aim of this research was to know comparison of antidislipidemia effect between extra virgin olive oil and Simvastatin on lipid profile in white mice. This way a laboratory experimental study using completely randomized design. Lipid profile was measured after 28 days treatment of extra virgin olive oil 0,225 ml/200 gram of body weight /day; 0,45 ml/200 gram of body weight/day; 0,9 ml/200 gram of bady weigh/day, and Simvastatin 0,18 mg/200 gram of body weight/day. Simvastatin (p=0,001) and extra virgin olive oil 0,225 ml/200 gram of body weight /day (p=0,017); 0,45 ml/200 gram of body weigh/day (p=0,002); 0,9 ml/200 gram of body weight/' (p=0,001) resulted in significant decrease of total cholesterol level. Simvastatin (p=0.007) and extra virgin olive oil 0,225 ml/200 gram of body weigh /day (P=0,005) resulted in significant increase of triglyceride level. Simvastatin (p=0,001) and extra virgin olive 0.9 ml/200 gram of body weight (p=0,509) resulted in unsignificant increased of HDL level. Simvastatin (p=0,001) and extra virgin olive oil 0,225 ml/200 gram of body weight/day(p=0,11); 0,45 ml/200 ,gram of body weight/day (p=0,010); 0,9 ml/200 gram of body weight/day (p=0,010) resulted in significant decreased of LDL level. The result show the same antidyslipidemia effect between extra virgin olive oil and simvastatin.

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