Tinjauan Molekular Dan Aspek Klinis Resistensi Insulin  

Oleh:

Sulistyoningrum, Evy

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Mandala of Health (A Scientific Journal) vol. 04 no. 02 (May 2010), page 131-138.
Topik: insulin resistance; pathomechanism; diagnosis; HOMA-IR index

Ketersediaan

Perpustakaan FK Nomor Panggil: M50.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Insulin resistance is defined by an unresponsive condition in the target organ that normally responded ta insulin hormone. Insulin resistance play a major role in many serious health problem such as metabolic syndrome, type II diabetes, polycistic ovarii syndrome, cancer and cardiovascular diseases. The mechanism of insulin resistance is still unclearly understood Researchers postulated two mechanism of insulin resistance, based on inflammatory theory and obesity theory. These two causes of insulin resistance have diferend mechanism of action. Clinical diagnosis of insulin resistance can be performed by clamp method and minimal model off equency sampled intravenous glucose tolerance test (FSIVGTT) but these gold standard diagnosis are very invasive. Non-invasive methods for diagnosing insulin resistance can be performed by using various formulas derived from base examination in glucose and insulin plasma level. One of the formulas which have high sensitivity and specificity is HOMA-IR index (Homeostasis Model Assessment-Insulin Resistance). Different characteristic of population required different cut-off for determining insulin resistant condition.

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