Pengaruh Pemberian Simetidin Terhadap Kadar SGOT dan SGPT Tikus Putih (Rattus norvegicus) Yang Diberi Anti Tuberkulosis Rifampisin dan Isoniazid  

Oleh:

Perdini, Eska ; Siswandari, Wahyu ; Pribadi, Fajar Wahyu

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Mandala of Health (A Scientific Journal) vol. 04 no. 02 (May 2010), page 97-104.
Topik: TUBERCULOSIS; PULMONARY; isoniazid; rifampisin; cimetidine; SCOT; SGPT

Ketersediaan

Perpustakaan FK Nomor Panggil: M50.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Tuberkulosis (TB) has long been known as an infection diseases, and has been reported to increased The INH dan Rifampisin are two different drugs that are known robe the most active drugs, therefore both drugs are being used as never ending drugs in curing the TB. Utilization of both INH and rivampisin in a combination to cure the TB patients, however could increase the possibility of hepar lession risk. This research was aimed to firstly, knowing whether cimetidine could prevent increase of SGOT and SGPT levels of rats (Rattus norvegicus) given by both drugs INH and rifampisin, and secondly what was the minimum dose of cimetidine that able to prevent the increase of SGOT and SGPT levels. A Completely Random Design (CRD) was applied in this research, 24 male rats (Rattus norvegicus) ofthe wistar variety were divided into 4 diferent groups. The first group, was only given the INH and rifampisin orally at the doses of 50 mg/Kg body weight/day, the next groups groups II, III, and IV were also given those two drugs at the same dose, but the cimetidine was also given at 112,5 , 225, and 450 mdKg body weigh/day for the 28 days. Consequently the SGOT and SGPT levels were measured twice pre and post treatments. The data obtained were analysied by the paired t test, a one way ANOVA, Post Hoc Tukey 's HSD, Kruskai- Watlis and Mann- Whitney test. This research result showed that the cimetidine that given following the INM and rifampisin could prevent the increase of SGOT and SGPT levels. The highest dose of 450 mg/Kg body weight/day that given orally shaved highly signijkant dryerent from other (p<0,00) in preventing the SGOT and SGPT of treated animals.

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