Tinjauan Histologis Pembuluh Darah Tikus Putih (Rattus norvegicus) Diabetes Yang Diberi Rebusan Daging Buah Mahkota Dewa (Phaleria macrocarpha (Scheff.) Boerl.)  

Oleh:

Kautsari, Septina ; Susantyo, Priyo ; Sulistyoningrum, Evy

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Mandala of Health (A Scientific Journal) vol. 04 no. 02 (May 2010), page 92-96.
Topik: DIABETES MELLITUS; Mahkota Dewa; (Phaleria rnacrocarpha (Schefl) Boerl); diabetes; aloxan; aterosklerosis.

Ketersediaan

Perpustakaan FK Nomor Panggil: M50.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Prevalence of Diabetes Mellitus among adult in Indonesia reached 4,I% in 1995 and projected to 6,5 % in 2025. Complication of diabetes mellitus which come earlier and widely distributed yis atherosclerosis. Atherosklerosis can lead to other serious complications such as gangrene, stroke, cardiomiopathy, and coronary artery diseases. This research was aimed lo know the effect of Mahkota Dewa (Phaleria macrocarpha) (Scheff) Boerl.) boiled water to regeneration of aorta's atherosclerosis post diabetic induction with alloxan. The research was conduct in four weeks to 25male albino rats (Rattus norvegicus) 3 month aged, 120-180 grama weighed The subjects was divided into five groups:positive control, negative control, A, B and C. A, B and C groups was treated Mahkota dewa boiled water with 4,5%, 9%, and 13,5% concentration respectively. The drug was administered orally. III, IV, and V groups are injected by allaran to induce diabetes. Atherosclerosis frequency was counted from histological section stained with Haematoxylineosin. Statistical analysis using Chi square analysis showed that Mahkota dewa boiled water significantly reduced atherosclerosis frequency in aorta. It can be concluded that Mahkota dewa (P.macrocarpha (Scheff) Boerl.) regenerates atherosclerosis injury in diabetic blood vessel.

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