Dendritic cells are equally distributed in intrauterine and tubal ectopic pregnancies  

Oleh:

Kemp, Birgit ; Schmitz, Svenja ; Krusche, Claudia A. ; Rath, Werner ; Rango, Ulrike von

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 01 (Jan. 2011), page 28-32.
Topik: ectopic pregnancy; intrauterine pregnancy; fetomaternal tolerance; dendritic cells; DC83; DEC205; DC-SIGN

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To examine different stages of dendritic cells (DCs) in intrauterine (IUPs) and viable tubal (VTPs) pregnancies to further elucidate mechanisms of fetomaternal tolerance and extravillous trophoblast invasion. Design Experimental study on patient-controlled material. Setting University hospital. Patient(s) Seven women with normal IUPs and ten with VTPs in the first trimester. Intervention(s) Suction curettage in IUP, laparoscopy in VTP. Main Outcome Measure(s) Immunohistochemistry for cytokeratin-7 (trophoblast), CD83 (mature DCs), DEC205 (activated but not fully mature DCs), DC-SIGN (immature macrophage-like DCs), and CD14 (macrophages) alone and in double staining. Result(s) The numbers of CD83+ and DEC205+ cells were similarly low in IUP and VTP (0.83 and 0.44 cells/mm2; 2.28 and 2.96 cells/mm2). The number of DC-SIGN+ cells was higher, though without significant differences among the entities examined (57.5 and 47.4 cells/mm2). About two-thirds of DC-SIGN+ cells were also CD14+ in IUP and VTP. Conclusion(s) The almost equal distribution of CD83+, DEC205+, and DC-SIGN+ cells in IUP and VTP suggests analogue control mechanisms in intrauterine and extrauterine DC differentiation and a comparable role of these DCs for the development of fetomaternal tolerance.

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