Influence of Thyroid Hormones and Transforming Growth Factor-beta1 on Cystatin C Concentrations  

Oleh:

Kotajima, N ; Yanagawa, Y ; Aoki, T

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 04 (Jul. 2010), page 1365-1373.
Topik: cystatin C; Graves' disease; hyperthyroidism; hypothyroidism; thyroid hormone; transforming growth factor-ß1 (TGF-ß1); 3; 5; 3'-tri-iodothyronine (T3); free thyroxine (T4)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Serum cystatin C concentrations are reported to increase in the hyperthyroid state. Serum concentrations of cystatin C and transforming growth factor-beta1 (TGF-beta1) were measured in patients with thyroid dysfunction, and the effects of 3,5,3Œ-triiodothyronine (T3) and TGF-beta1 on cystatin C production in human hepatoblastoma (Hep G2) cells were studied. Serum concentrations of cystatin C and TGF-beta1 were significantly higher in patients with Gravesf disease compared with control subjects. Significantly positive correlations were observed between thyroid hormones and cystatin C, thyroid hormones and TGF-beta1, and TGF-beta1 and cystatin C in patients with thyroid dysfunction. Serum concentrations of cystatin C and TGF-beta1 decreased after treatment for hyperthyroidism. Cystatin C mRNA levels and cystatin C secretion were increased by T3 and TGF-beta1 in cultured Hep G2 cells. These results suggest that serum cystatin C concentrations increase in patients with hyperthyroidism. The mechanisms for this may involve elevation of serum TGF-beta1 levels and the stimulatory effects of T3 and TGF-beta1 on cystatin C production.

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