Bioactive Protein Fraction DLBS1033 Exerts its Positive Pleiotropic Effects in the Vascular Cells via Down Regulation of Gene Expression  

Oleh:

Kurnia, Frans ; Tjandrawinata, Raymond Rubianto

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: MEDICINUS (Scientific Journal of Pharmaceutical Development and Medical Application) vol. 24 no. 1 (Jan. 2011), page 18-24.

Ketersediaan

Perpustakaan FK Nomor Panggil: M56.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

There is accumulating evidence suggesting that cardio- and cerebrovascular diseases have a positive correlation with the events of inflammation that in addition to plaque instability occurs in the vasculature. Providing a therapy that exerts its anti-inflammatory action and inhibition of proliferation and migration of smooth muscle cells may be promising and effective in fighting the cardiovascular disease (CVD). The bioactive protein fraction DLBS1033 is shown to posses such activities. DLBS1033 down-regulates inflammatory markers including JAK1, STAT1, TNFa, NF-kB as well as decreasing vascular smooth muscle cells proliferation and migration. As Matrix Metaloproteinase-9 (MMP-9) expression was downregulated by DLBS1033, it was suggested that DLBS1033 also permitted plaque stabilization to occur in the vasculature. Taken together, these data suggest DLBS1033 exerts its positive pleiotropic effects on the vascular cells primarily via its anti inflammatory activities, plaque stabilization, vascular smooth muscle cells inhibition of proliferation and migration.

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