Detail 25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end (from Nature Reviews Immunology, 2013, 13, 535-542) Bibliografi Author: Heim, Markus H. Topik: Hepatitis C; Hepatitis - Drug Bahasa: (EN )     Penerbit: Macmillan Publishers Limited     Tahun Terbit: 2013     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: heim2013.pdf (523.34KB; 0 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract Chronic hepatitis caused by infection with hepatitis C virus C (HCV) (therefore known as chronic hepatitis C (CHC)) is a leading cause of liver disease worldwide. For the past 25 years, recombinant interferon-a (IFNa) has been the main component of treatments for HCV infection. Treatment efficacy has shown a stepwise improvement following the pegylation of IFNa and its use in combination with other antiviral drugs. However, viral escape mechanisms, refractory IFNa signalling in the liver and substantial drug toxicity still limit the efficacy of this treatment. A new generation of HCV-specific antiviral drugs will probably improve response rates and might replace IFNs in CHC treatment in the next few years. This Timeline article summarizes the history of CHC treatment using recombinant IFNa with an emphasis on the mechanisms of action and the causes of non-response. [hepatitis - drug] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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