Detail A novel strategy to inhibit the reproduction and translation of hepatitis C virus (from Science China, Life Sciences, 2013, 56 (4), 293-297) Bibliografi Author: Ai-Ping, Duan ; Li-Min, Ning ; Chao, Li ; Ya-Fei, Hou ; Na-Na, Yang ; Li-Zhou, Sun ; Gen-Xi, Li Topik: Hepatitis C virus; Reproduction and translation; Argonaute 2 protein; Electro-analysis; Biosensor; Hepatitis - Drug Bahasa: (EN )     Penerbit: The Author(s)     Tahun Terbit: 2013     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: art_3A10.1007_2Fs11427-013-4468-2.pdf (570.6KB; 0 download) Abstract Hepatitis C virus (HCV), a positive single-stranded RNA virus, is a major cause of liver disease in humans. Herein we report a novel strategy to inhibit the reproduction and translation of HCV using a short RNA, named an Additional RNA, to activate the endonuclease activity of Argonaute 2 (Ago2). In the presence of the Additional RNA, the HCV genome RNA has the requisite 12 nucleotides of base-pairing with microRNA-122. This activates the endonuclease activity of Ago2, resulting in cleavage and release of the HCV genome RNA from Ago2 and microRNA-122. The free HCV genome RNA would be susceptible to intracellular degradation, effectively inhibiting its reproduction and translation. This study presents a new method to inhibit HCV that may hold great potential for HCV treatment in the future. [hepatitis - drug] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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